Structure and mechanism of non-histone protein acetyltransferase enzymes
نویسندگان
چکیده
منابع مشابه
Structure and function of histone acetyltransferase MOF.
MOF was first identified in Drosophila melanogaster as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and similar enzymatic activities. MOF plays importa...
متن کاملStructure of Patt1 human proapoptotic histone acetyltransferase
The results of modeling of a novel human histone acetyltransferase Patt1 are presented here. This protein belongs to the GNAT GCN5 family and shows proapoptotic activity in human hepatocellular carcinoma cells. Patt1 is an attractive therapeutic target. The sequence analysis, fold recognition predictions and homology modeling of Patt1 protein structure were performed. N- and C- termini of Patt1...
متن کاملStructure and mechanism of action of the histone acetyltransferase Gcn5 and similarity to other N-acetyltransferases.
An important posttranslational modification of histones is acetylation of -amino groups on conserved lysine residues present in the amino-terminal tails of these proteins. Acetylation neutralizes the positively charged lysines and therefore affects interactions of the histones with other proteins and or with DNA. Histone acetylation has long been associated with transcriptionally active chromat...
متن کاملInvestigation of the Acetylation Mechanism by GCN5 Histone Acetyltransferase
The histone acetylation of post-translational modification can be highly dynamic and play a crucial role in regulating cellular proliferation, survival, differentiation and motility. Of the enzymes that mediate post-translation modifications, the GCN5 of the histone acetyltransferase (HAT) proteins family that add acetyl groups to target lysine residues within histones, has been most extensivel...
متن کاملKinetic mechanism of the histone acetyltransferase GCN5 from yeast.
The transcriptional coactivator GCN5 from yeast (yGCN5) is a histone acetyltransferase that is essential for activation of target genes. GCN5 is a member of a large family of histone acetyltransferases that are conserved between yeast and humans. To understand the molecular mechanisms of histone/protein acetylation, a detailed kinetic analysis was performed. Bi-substrate kinetic analysis using ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Journal
سال: 2013
ISSN: 1742-464X
DOI: 10.1111/febs.12373